Isaac by Dreamest

Bob's Curse: Bombs will now deal 20% of their damage as damage over time. Replenishes all bomb charges.

Mom's Heels: Increase Isaac's auto attack range by 10%.

Ball of Tar: Shortly after being hit, Isaac will lay down black creep, slowing enemies that step on in by 20% for two seconds. 10 seconds internal cooldown.

Burnt Penny: Coins have a 10% chance to spawn a bomb pick up.

Counterfeit Penny: Coins have a 10% chance to give double value.

Bloody Penny: Coins have a 10% chance to spawn half a heart(10% of max HP on pick up)

***** of Babylon: When below 20% of his max HP or 400 health, movement speed increased by 15% and auto attack damage increase by 40%.

The Mark: Increase auto attack damage by 15%.

Bloody Lust: Every kill(on ANYTHING) increases Isaac's damage by 0.2%. This will stack indefinitely but all stacks will be removed after not attacking anything for 10 seconds. Isaac must've dealt damage to the target within 3 seconds for it to be considered a kill. After a re-roll the buff can be maintained but not increase.

Mr. Mega: Bombs now deal 50% more damage. Reduces charge amount to 2. Refills bombs on picking this talent.

Brother Bobby: Spawn a familiar that will fire shots dealing half of Isaac's damage. Brother Bobby will not shoot at a target but to the area Isaac's tears are flying. Will only hit the first target hit.

Robo-Baby: Spawns a familiar that will fire laser, dealing 20% of Isaac's damage. Robo-baby will fire at the area Isaac is firing at, but not at a specific target. Shots pierce through all enemies.

Leech: Spawns a familiar that will chase enemies after they've been in melee range of Isaac until they're out of his vision. For every 20 times Leech hits an enemy hero, it'll heal Isaac for 25% of his health.

Polyphemus: Increase auto attack damage by 100%. Reduce attack speed by 50%. Auto attacks now pierce through enemies and can deal up to three hits.

Skinny Odd Mushroom: Increases attack speed by 50% while reducing attack damage by 15%.

Epiphora: Increases attack speed by 5% for every auto attack on the same target while not moving, stacks up to 150%.

Scatter Bomb: Your bombs will now spawn 2-4 bombs after exploding.

Guppy Upgrade - Spider Baby: Instead of flies, Isaac will spawn spiders that deal 200% auto attack damage.

Mom's Knife Upgrade - Brimstone: After firing Mom's Knife, Isaac will have a volley of knives flying in the direction of your cursor, dealing 10% auto attack damage as magic.

Krampus's Head:
Cooldown: 100 auto attacks.
Isaac will fire a large laser that deals attack damage as magic in his four diagnostically directions. Brimstone can hit up to 5 times.

D100: Rerolls all of Isaac's talents except his level 10 and 20. Isaac will get 5 points(one for each tier+1 extra). These points will be placed into RANDOM talents between all tiers. This has internal cooldown of 5 levels(will be active again at 25 and 30 if used at 20)