Bad against:
Illidan: Evade allows Illidan to avoid getting hit by basic attacks and since Zenyatta has no damaging abilities besides
Dissonance, this is a bad matchup for him.
Blaze: Pyromania grants so much
Armor that even with
Orb of Discord it's too much.
Samuro: Mirror Image does not only make it harder for Zenyatta to use
Orb of Discord on the right target, but it also allows Samuro to kill Zenyatta easily.
Others:
-Heroes that can evade basic attacks.
-Heroes with too much
Armor.
-Heroes that can mess with target management.
Good Against:
Li-Ming: Thanks to her low health and all abilities being skillshots (if Zenyatta is evasive enough),
Orb of Discord can make her survivability much weaker.
Genju: Genji's damage can be quite outhealed with
Orb of Harmony (if played safe). He is also quite vulnerable without
Deflect.
Murky: His low health is enough to make him vulnerable against Zenyatta, even without
Orb of Discord.
Others:
-Heroes with low health.
-Heroes that rely on a certain ability to survive.
Works well with:
Tracer: Orb of Discord allows Tracer to deal way more damage against a certain enemy hero.
Tyrael: Orb of Harmony allows Tyrael to survive more in fights. Additionally,
Righteousness's shield gives more survivability to Zenyatta.
Others:
-Heroes that can benefit a lot from armor reduction.
-Heroes that can give shields to allies.
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