Written for Khael'Thas Patch Juny 2015
I have created this build in a non-squishy team that can assault enemy-dps pretty well, in a combat of course. It supports Tychus being very durable, allowing him to make use of ALL of his spells effectively and even his passive thus his short ranged auto attack, more.
The upside is he is not only reliant on Overkill (q) and Commandeer Odin (r) but can also do all other sorts of stuff, however the biggest plus is still the Odin, albeit not a maximized-damage-odin.
The downside ? "Less" range, less of the other builds, bad build without 'assaultish' allies.

1: Regeneration Master This talent doesn't seem very strong on Tychus at first. It has many aspects that help us though:
It is decent early on & it synergyses extremly well with all the other talents. Because who needs health regen who is squishy? (a usual Tychus.) With the extra defense from following talents this is useful throughout the game.
Variant 1: Scouting Drone Consider this against cloaked units, especially on Blackheart's Bay. While it doesn't reveal them, you can much earlier see the cloak and of course other enemies. It weakens your build, but it's quite supportive.

4: Melting Point This makes us clear waves faster which synergies well with Regeneration Master, also not only does it allow us to start walking to our team and objectives but also clear those ;) and of course the damage will help in clearing out keeps and towers more effectively, which is good because you (and your team) can retreat earlier and go for objectives or help elsewhere! "PvE is not bad"

7: First Aid General big heal on demand in a fight. Synergy to our other talents. Make sure to use it early enough (6 seconds!)
Variant 7: Sizzlin' Attacks This ability is generally frowned upon(!) due to Tychus' natural low range of 4.5 as opposed to other assasin's 5.5 range. However it fits quite well to our build later on and is especially strong on the Commandeer Odin (10). Unfortunately not yet at level 7. Only go for this talent, if you know what you are doing.

10: Commandeer Odin We got a real Odin, a true THOR that is tanky and not one of these paper thors you often see ;) while naturally dishing out alot of damage, it allows us to help extremly well in a teamfight and attack enemy dps. Always say "Thor is here" when activating this, it will increase damage of the first hit

13: Relentless This is required versus any competitive assault on you. Synergy to our general build and gameplay.

16: Stoneskin Another "heal" when used in the right time.

20: Bolt of the Storm Generally supporting our gameplay, defensively but also offensively! Strengthens Thor's offensive capabilities more than Big Red Button itself.
Variant 20: Big Red Button If you feel fights are lasting too long and you do not need Blink really, this is for you.

Written for Khael'Thas Patch Juny 2015
Decide for yourself wether the content of this guide is still useful for your current version.

Butcher Patch July 2015:
Melting Point NERFED from 120 (+50/lvl) to 200 (+30/lvl)
Buff of ranged Attack +1
Buff of Regeneration Master +1.5 HP-regen for each globe, but removed the initial +4 regen.