Muradin is a warrior who can deal damage or never die. His talents include

Q Stormbolt (Throw a hammer,dealing 240 (50 + 10 per level) to the first enemy hit and stunning it for 1.5 seconds.)

W Thunderclap(deals 210 (58 + 8 per level) and slows enemies by 25% for 2.5 seconds.)

E Dwarf Toss (Leap to target location,dealing 130 (35 + 5 per level)to enemies on landing.)

D Second Wind (Restore 84 (15.6 + 3.6 per level) Health per second when you have not taken damage for 4 seconds. When below 40% Health, increased to 168 (31.2 + 7.2 per level) Health per second.)

R1 Avatar (Transform for 20 seconds, gaining 2240 (416 + 96 per level) Health and causing your Basic Attacks to stun enemies.)

R2 Haymaker (Stun target enemy Hero, and wind up a punch dealing 700 (320 + 20 per level) damage and knocking the target back, hitting enemies in the way for 175 (80 + 5 per level) damage and knocking them aside.)

http://us.battle.net/heroes/en/heroes/muradin/#abilities

For this talent I like to go with Perfect Storm because later in the game muradin does 1k with his stormbolt, so P.S. will just add on to that. But if you face nova you might want to get block

Sledge hammer really is one of the best talents here, but if you face a team with a lot of dps, then third wind is a good choice.

This is the best talent for muradin. it goes perfect with Perfect Storm. The only exception is tychus, then you could get skullcracker

Here I like Haymaker because it is very fun and powerful, but if you are the only tank, get avatar

Burning rage is nice, some more damage, but usually if you are a solo tank or if you face a nova, you should get spell shield

Dwarf Toss And Stoneform are nice, but most of the talents here aren't great.

If you get haymaker, definitely get grand slam, otherwise get rewind

Here block is the best way to go

For this talent i would choose third wind, that way you can fight, move away, fight. This strategy works in places like Dragon Shire, Black Hearts Bay and Cursed Hollows

Pierce is the best talent, but if you face a Tychus then maybe go Skullcracker

Haymaker is good but if you are the only tank go avatar, or if you just want to be as tanky as possible then avatar is best

I like spell shield here, but another possibility is healing static

Stone form is best if you don't go third wind but if you pick both then be aware that it now has a cool down, so it might not be the best at cursed hollow, if you don't pick it then go Dwarf Launch.

Really this is your choice. My favorite is Grand slam, but if you want to be tanky, go with Hardened Shield